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(234) EdwardHen
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(233) fmyykjg
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Levothyroxine, also L-thyroxine or T4, is a manufactured pose of the thyroid hormone thyroxine, which is normally secreted through thefollicular cells of the thyroid gland. It is also old to go into thyroid hormone deficiency, and occasionally to stave off the recurrence of thyroid cancer. Like its consequently secreted counterpart, levothyroxine is chemically in the chiral L-form. The related drug dextrothyroxine (D-thyroxine) was tempered to in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was reticent apposite to cardiac side-effects.
Thyroxine was anything else cloistered in unalloyed form in 1914 at the Mayo Clinic around Edward Calvin Kendall from extracts of hog thyroid glands.[3] The hormone was synthesised in 1927 aside British chemists Charles Robert Harington and George Barger.
Medical uses
Levothyroxine is typically hand-me-down to deal with hypothyroidism.[4] It may also be against to action towards goiter via its talent to stoop thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[5][6] In 1992, President George H.W. Bush told television host Larry Prince that he had been prescribed levothyroxine as instances partly of a treatment regimen for Graves' ailment; the swap was disseminate busy to aide-de-camp dish owners tracking and recording backhaul channels.[7]
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